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مروری بر اثرات متقابل بین ریزجلبک‌ها و آنتی‌بیوتیک‌های فاضلاب‌های شهری و صنعتی

نوع مقاله : مقالات مروری روایی و یکپارچه

نویسندگان

1 دانشیار دپارتمان زیست شناسی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران.

2 دانشجوی کارشناسی ارشد بیوتکنولوژی میکروبی، دپارتمان زیست شناسی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران.

چکیده

زمینه و هدف: آنتی‌بیوتیک‌های باقی‌مانده از فاضلاب‌های شهری و صنعتی، به طور مداوم در محیط‌های آب شیرین حاوی ریزجلبک‌ها آزاد می‌شوند و آن‌ها را به مخزنی تبدیل می‌کنند که به افزایش مقاومت آنتی‌بیوتیکی منجر می‌شود؛ بنابراین، درک اثرات باقی مانده آنتی‌بیوتیک‌ها بر ریزجلبک‌ها به دلیل نقش حیاتی آن‌ها به‌عنوان تولیدکنندگان اولیه در اکوسیستم، ضروری است.

مواد و روش‌ها: در این مقاله مروری، بیش از 200 نشریه معتبر با جزییات مورد بررسی قرار گرفته است. به این منظور جستجو از پایگاه‌های اطلاعاتی مانند Science Direct، Scopus، Web of Sciences و فهرست مجلات با دسترسی آزاد انجام شد و از کلیدواژه‌هایی مانند «ریزجلبک‌ها»، «تجزیه و حذف زیستی»، «جذب و تجمع زیستی»، «مکانیسم اثر طیف وسیعی از آنتی‌بیوتیک‌ها»، «اثرات هم‌افزایی و مقابله‌ای»، «اکتساب و انتقال ژن‌های مقاومت آنتی‌بیوتیکی» و «جهش‌های حاصل از آنتی‌بیوتیک‌ها» استفاده گردید.

یافته‌ها: مقاومت ایجاد شده در مقابل آنتی‌بیوتیک‌ها در ریزجلبک‌ها با افزایش نرخ فتوسنتز، فعالیت آنتی‌اکسیدانی و تولید سم همراه است، در حالی که استرس اکسیداتیو و رشد کاهش می‌یابد. بنابراین حضور بیشتر توده‌های سیانوتوکسین‌ها به‌ویژه نزدیک خروجی‌های تصفیه‌خانه‌های فاضلاب، می‌تواند نقش مهمی برای حذف ژن‌های مقاوم به آنتی‌بیوتیک داشته باشد.

نتیجه‌گیری: ارتباط مستقیمی بین میزان آنتی‌بیوتیک‌ها و افزایش تولید سموم ریزجلبک‌ها وجود دارد که این نشان می‌دهد ریزجلبک‌ها با گذشت زمان به آنتی‌بیوتیک‌ها مقاوم می‌شوند و به این ترتیب می‌توانند نقش حیاتی در حذف ROS اضافی ناشی از قرار گرفتن در معرض آنتی‌بیوتیک ایفا کنند.

کلیدواژه‌ها

عنوان مقاله [English]

Review of the Interactions between Cyanobacteria and Antibiotics in Urban and Industrial Wastewaters

نویسندگان [English]

  • Bahareh Nowruzi 1
  • Narjes EtminanZadeh 2
  • Anaita Sobhani 2

1 Associate professor, Department of Biology, SR.C., Islamic Azad University, Tehran, Iran.

2 M.Sc. Student in microbial Biotechnology, Department of Biology, SR.C., Islamic Azad University, Tehran, Iran.

چکیده [English]

Background and Objective: Antibiotic residues from urban and industrial wastewater discharge and agricultural runoff are continuously released into freshwater environments, turning them into reservoirs that contribute to increased antibiotic resistance. Therefore, understanding the effects of antibiotic residues on aquatic organisms, especially cyanobacteria, is essential due to their vital role as primary producers in ecosystems.

Materials and Methods: In this review article, over 200 reputable publications related to the effects of antibiotics on major biological processes in cyanobacteria-including photosynthesis, oxidative stress, and macromolecule metabolism-are examined in detail. The mechanisms of their adaptation to antibiotic exposure are also thoroughly reviewed. To this end, searches were conducted in databases such as Science Direct, Scopus, Web of Sciences, and open-access journal lists, using keywords like "cyanobacteria," "biodegradation and bioremediation," "bioaccumulation and biomagnification," "activation of antioxidant systems," "mechanism of action of a wide range of antibiotics," synergistic and antagonistic effects," "acquisition and transfer of antibiotic resistance genes," and "mutations induced by antibiotics."

Results: The antibiotic resistance developed in microalgae is associated with an increased rate of photosynthesis, antioxidant activity, and toxin production, while oxidative stress and growth decrease. Therefore, the higher presence of cyanotoxin biomass, especially near wastewater treatment plant outlets, may play an important role in the removal of antibiotic resistance genes.

Conclusion: There is a direct correlation between the levels of antibiotics and the increased production of microalgal toxins, indicating that microalgae become resistant to antibiotics over time and thus can play a vital role in eliminating the excess ROS generated from antibiotic exposure.
 
Open Access Policy: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/

کلیدواژه‌ها [English]

  • Mechanism of Action of a Wide Range of Antibiotics: Antibiotic Resistance
  • Biodegradation
  • Transfer of Antibiotic Resistance Genes
  • Synergistic and Antagonistic Effects
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مجله پژوهش در بهداشت محیط
دوره 11، شماره 2 - شماره پیاپی 42
شهریور 1404
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