Document Type : Narrative and integrative review
Authors
1 Pharm.D, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2 Assistant Professor, Department of Pharmaceutical Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Associate Professor, Department of Pharmaceutical Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Professor, Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
5 Professor, Department of Pharmaceutical Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Background and Purpose: Essential oils (EOs) are natural compounds with various properties. In terms of physical characteristics, they are oily, lipophilic, and have a unique smell. Studies and observations have proven their antibacterial, anti-fungal, and antiviral properties. Considering the diversity of climatic conditions and vegetation of Iran, in this article, we have tried to discuss the native plants of Iran and the EOs extracted from them, along with their properties, focusing on the antiseptic properties and their components from the past to now. Moreover, these compounds' extraction methods and chemical structures have also been briefly reviewed.
Materials and Methods: Using several different databases, including Scopus, PubMed, Web of Science, Google Scholar, and Science Direct (without time limit), and using the names of EOs alongside the keywords of disinfection and antimicrobial, a screening search was done until the end of 2023. By limiting the search, irrelevant and duplicate studies were excluded, and articles were screened after reviewing the titles, abstracts, and full texts.
Results: According to the studies, the disinfectant property of EOs is clear; in some cases, they have been used to prevent and treat the SARS-COV-2 virus, and have antibacterial effects against antibiotic-resistant bacteria and biofilm-producer strains.
Conclusion: Successful primary treatment lines from these compounds are expected to be reported soon. Finally, due to their widespread use, EOs can be considered an integral part of human life throughout history.
Open Access Policy: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/
Keywords
- Edris AE. Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: a review. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2007; 21(4): 308-23. https://doi.org/10.1002/ptr.2072
- Carson CF, Hammer KA. Chemistry and bioactivity of essential oils. Lipids and essential oils as antimicrobial agents. 2011: 203-38. https://doi.org/10.1002/9780470976623.ch9
- Hussain AI, Anwar F, Hussain Sherazi ST, Przybylski R. Chemical composition, antioxidant and antimicrobial activities of basil (Ocimum basilicum) essential oils depends on seasonal variations. Food Chemistry. 2008; 108(3): 986-95. Epub 20071214. https://doi.org/10.1016/j.foodchem.2007.12.010
- Wani AR, Yadav K, Khursheed A, Rather MA. An updated and comprehensive review of the antiviral potential of essential oils and their chemical constituents with special focus on their mechanism of action against various influenza and coronaviruses. Microbial Pathogenesis. 2021; 152: 104620. Epub 20201116. https://doi.org/10.1016/j.micpath.2020.104620
- Asili J, Emami SA, Eynolghozat R, Noghab ZS, Bazzaz BSF, Sahebkar A. Chemical composition and in vitro efficacy of essential oil of seven Artemisia species against ESBL producing multidrug-resistant Escherichia coli. Journal of Essential Oil Bearing Plants. 2015; 18(1): 124-45. https://doi.org/10.1080/0972060X.2014.895181
- Ramsey JT, Shropshire BC, Nagy TR, Chambers KD, Li Y, Korach KS. Essential oils and health. Yale Journal of Biology and Medicine. 2020; 93(2): 291-305.
- Fournier G, Hadjiakhoondi A, Leboeuf M, Cavé A, Fourniat J, Charles B. Chemical and biological studies of Xylopia longifolia A. DC. essential oils. Journal of Essential Oil Research. 1993; 5(4): 403-10. https://doi.org/10.1080/10412905.1993.9698250
- Panda SK, Buroni S, Swain SS, Bonacorsi A, da Fonseca Amorim EA, Kulshrestha M, et al. Recent advances to combat ESKAPE pathogens with special reference to essential oils. Frontiers in Microbiology. 2022; 13: 1029098. Epub 20221206. https://doi.org/10.3389/fmicb.2022.1029098
- Ali SS, Ahmad N, Jamal Gilani S, Ali Khan N. Isothiocyanates: a review. Research Journal of Pharmacognosy. 2018; 5(2): 71-89.
- Iranshahy M, Bazzaz SF, Haririzadeh G, Abootorabi BZ, Mohamadi AM, Khashyarmanesh Z. Chemical composition and antibacterial properties of Peganum harmala L. Avicenna journal of phytomedicine. 2019; 9(6): 530.
- Asili J, Sahebkar A, Bazzaz BSF, Sharifi S, Iranshahi M. Identification of essential oil components of Ferula badrakema fruits by GC-MS and 13C-NMR methods and evaluation of its antimicrobial activity. Journal of Essential Oil Bearing Plants. 2009; 12(1): 7-15. https://doi.org/10.1080/0972060X.2009.10643685
- Mcdonnell G, Hansen JM. Essential Oils. Block's Disinfection, Sterilization, and Preservation. 6th ed. China: Lippincott Williams & Wilkins; 2021. p. 777-812.
- de Groot AC, Schmidt E. Essential Oils, Part III: Chemical Composition. Dermatitis. 2016; 27(4): 161-9. https://doi.org/10.1097/DER.0000000000000193
- Bilia AR, Guccione C, Isacchi B, Righeschi C, Firenzuoli F, Bergonzi MC. Essential oils loaded in nanosystems: a developing strategy for a successful therapeutic approach. Evidence Based Complementary and Alternative Medicine. 2014; 2014: 651593. Epub 20140529. https://doi.org/10.1155/2014/651593
- Espina L, Somolinos M, Lorán S, Conchello P, García D, Pagán R. Chemical composition of commercial citrus fruit essential oils and evaluation of their antimicrobial activity acting alone or in combined processes. Food control. 2011; 22(6): 896-902. https://doi.org/10.1016/j.foodcont.2010.11.021
- Ntalli NG, Ferrari F, Giannakou I, Menkissoglu-Spiroudi U. Synergistic and antagonistic interactions of terpenes against Meloidogyne incognita and the nematicidal activity of essential oils from seven plants indigenous to Greece. Pest Management Science. 2011; 67(3): 341-51. Epub 20101217. https://doi.org/10.1002/ps.2070
- Fornari T, Vicente G, Vázquez E, García-Risco MR, Reglero G. Isolation of essential oil from different plants and herbs by supercritical fluid extraction. Journal of Chromatography A. 2012; 1250: 34-48. Epub 20120426. https://doi.org/10.1016/j.chroma.2012.04.051
- FAZLI BB, Rezaei A, Iranshahi M, NADERI NM, KHAJEH KAM. Evaluating the potentiating effect of galbanic acid from Ferula szowitsiana on three common antibiotics against resistant hospital isolates of Staphylococcus aureus. 2009.
- Caniard A, Zerbe P, Legrand S, Cohade A, Valot N, Magnard JL, et al. Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture. BMC Plant Biology. 2012; 12: 119. Epub 20120726. https://doi.org/10.1186/1471-2229-12-119
- Bou DD, Lago JH, Figueiredo CR, Matsuo AL, Guadagnin RC, Soares MG, et al. Chemical composition and cytotoxicity evaluation of essential oil from leaves of Casearia sylvestris, its main compound α-zingiberene and derivatives. Molecules. 2013; 18(8): 9477-87. Epub 20130808. https://doi.org/10.3390/molecules18089477
- Rao VP, Pandey D. Extraction of essential oil and its applications 2007.
- Tongnuanchan P, Benjakul S. Essential oils: extraction, bioactivities, and their uses for food preservation. Journal of Food Science. 2014; 79(7): R1231-49. Epub 20140602. https://doi.org/10.1111/1750-3841.12492
- El Asbahani A, Miladi K, Badri W, Sala M, Aït Addi EH, Casabianca H, et al. Essential oils: from extraction to encapsulation. International Journal of Pharmaceutics. 2015; 483(1-2): 220-43. Epub 20150213. https://doi.org/10.1016/j.ijpharm.2014.12.069
- Melo AD, Amaral AF, Schaefer G, Luciano FB, de Andrade C, Costa LB, et al. Antimicrobial effect against different bacterial strains and bacterial adaptation to essential oils used as feed additives. Canadian Journal of Veterinary Research. 2015; 79(4): 285-9.
- Bazzaz BSF, Khameneh B, Ostad MRZ, Hosseinzadeh H. In vitro evaluation of antibacterial activity of verbascoside, lemon verbena extract and caffeine in combination with gentamicin against drug-resistant Staphylococcus aureus and Escherichia coli clinical isolates. Avicenna journal of phytomedicine. 2018; 8(3): 246.
- Hammer KA, Heel KA. Use of multiparameter flow cytometry to determine the effects of monoterpenoids and phenylpropanoids on membrane polarity and permeability in staphylococci and enterococci. International Journal of Antimicrobial Agents. 2012; 40(3): 239-45. Epub 20120712. https://doi.org/10.1016/j.ijantimicag.2012.05.015
- de Souza EL, de Barros JC, de Oliveira CE, da Conceição ML. Influence of Origanum vulgare L. essential oil on enterotoxin production, membrane permeability and surface characteristics of Staphylococcus aureus. International Journal of Food Microbiology. 2010; 137(2-3): 308-11. Epub 20091204. https://doi.org/10.1016/j.ijfoodmicro.2009.11.025
- Khan I, Bahuguna A, Kumar P, Bajpai VK, Kang SC. Antimicrobial potential of carvacrol against uropathogenic Escherichia coli via membrane disruption, depolarization, and reactive oxygen species generation. Frontiers in Microbiology. 2017; 8: 2421. Epub 20171206. https://doi.org/10.3389/fmicb.2017.02421
- Chauhan AK, Kang SC. Thymol disrupts the membrane integrity of Salmonella ser. typhimurium in vitro and recovers infected macrophages from oxidative stress in an ex vivo model. Research in Microbiology. 2014; 165(7): 559-65. Epub 20140715. https://doi.org/10.1016/j.resmic.2014.07.001
- de Sousa JP, Torres Rde A, de Azerêdo GA, Figueiredo RC, Vasconcelos MA, de Souza EL. Carvacrol and 1,8-cineole alone or in combination at sublethal concentrations induce changes in the cell morphology and membrane permeability of Pseudomonas fluorescens in a vegetable-based broth. International Journal of Food Microbiology. 2012; 158(1): 9-13. Epub 20120621. https://doi.org/10.1016/j.ijfoodmicro.2012.06.008
- Carson CF, Mee BJ, Riley TV. Mechanism of action of Melaleuca alternifolia (tea tree) oil on Staphylococcus aureus determined by time-kill, lysis, leakage, and salt tolerance assays and electron microscopy. Antimicrobial Agents and Chemotherapy. 2002; 46(6): 1914-20. https://doi.org/10.1128/AAC.46.6.1914-1920.2002
- Cox SD, Gustafson JE, Mann CM, Markham JL, Liew YC, Hartland RP, et al. Tea tree oil causes K+ leakage and inhibits respiration in Escherichia coli. Letters in Applied Microbiology. 1998; 26(5): 355-8. https://doi.org/10.1046/j.1472-765X.1998.00348.x
- Li X, Sheng J, Huang G, Ma R, Yin F, Song D, et al. Design, synthesis and antibacterial activity of cinnamaldehyde derivatives as inhibitors of the bacterial cell division protein FtsZ. European Journal of Medicinal Chemistry. 2015; 97: 32-41. Epub 20150424. https://doi.org/10.1016/j.ejmech.2015.04.048
- Aleksic V, Knezevic P. Antimicrobial and antioxidative activity of extracts and essential oils of Myrtus communis L. Microbiological Research. 2014; 169(4): 240-54. Epub 20131024. https://doi.org/10.1016/j.micres.2013.10.003
- Arnal-Schnebelen B, Hadji-Minaglou F, Peroteau J, Ribeyre F, De Billerbeck V. Essential oils in infectious gynaecological disease: a statistical study of 658 cases. International Journal of Aromatherapy. 2004; 14(4): 192-7. https://doi.org/10.1016/j.ijat.2004.09.003
- Tariq S, Wani S, Rasool W, Shafi K, Bhat MA, Prabhakar A, et al. A comprehensive review of the antibacterial, antifungal and antiviral potential of essential oils and their chemical constituents against drug-resistant microbial pathogens. Microbial Pathogenesis. 2019; 134: 103580. Epub 20190611. https://doi.org/10.1016/j.micpath.2019.103580
- Jassim SA, Naji MA. Novel antiviral agents: a medicinal plant perspective. Journal of Applied Microbiology. 2003; 95(3): 412-27. https://doi.org/10.1046/j.1365-2672.2003.02026.x
- Rivero-Cruz I, Duarte G, Navarrete A, Bye R, Linares E, Mata R. Chemical composition and antimicrobial and spasmolytic properties of Poliomintha longiflora and Lippia graveolens essential oils. Journal of Food Science. 2011; 76(2): C309-17. https://doi.org/10.1111/j.1750-3841.2010.02022.x
- Mendez M, Rodríguez R, Ruiz J, Morales-Adame D, Castillo F, Hernández-Castillo FD, et al. Antibacterial activity of plant extracts obtained with alternative organics solvents against food-borne pathogen bacteria. Industrial Crops and Products. 2012; 37(1): 445-50. https://doi.org/10.1016/j.indcrop.2011.07.017
- Brooker MIH, Kleinig DA. Field guide to eucalypts. 2nd Edn. Melbourne Blooming Books, Northern Australia2004.
- Pino JA, Marbot R, Quert R, García H. Study of essential oils of Eucalyptus resinifera Smith, E. tereticornis Smith and Corymbia maculata (Hook.) KD Hill & LAS Johnson, grown in Cuba. Flavour and fragrance journal. 2002; 17(1): 1-4. https://doi.org/10.1002/ffj.1026
- Loizzo MR, Saab AM, Tundis R, Statti GA, Menichini F, Lampronti I, et al. Phytochemical analysis and in vitro antiviral activities of the essential oils of seven Lebanon species. Chemistry & Biodiversity. 2008; 5(3): 461-70. https://doi.org/10.1002/cbdv.200890045
- Pérez-Vásquez A, Capella S, Linares E, Bye R, Angeles-López G, Mata R. Antimicrobial activity and chemical composition of the essential oil of Hofmeisteria schaffneri. Journal of Pharmacy and Pharmacology. 2011; 63(4): 579-86. Epub 20110301. https://doi.org/10.1111/j.2042-7158.2010.01243.x
- Bassolé IHN, Juliani HR. Essential oils in combination and their antimicrobial properties. Molecules. 2012; 17(4): 3989-4006. https://doi.org/10.3390/molecules17043989
- Zhou F, Ji B, Zhang H, Jiang H, Yang Z, Li J, et al. Synergistic effect of thymol and carvacrol combined with chelators and organic acids against Salmonella typhimurium. Journal of Food Protection. 2007; 70(7): 1704-9. https://doi.org/10.4315/0362-028X-70.7.1704
- Rodrigues FF, Costa JG, Coutinho HD. Synergy effects of the antibiotics gentamicin and the essential oil of Croton zehntneri. Phytomedicine. 2009; 16(11): 1052-5. Epub 20090612. https://doi.org/10.1016/j.phymed.2009.04.004
- Hemaiswarya S, Kruthiventi AK, Doble M. Synergism between natural products and antibiotics against infectious diseases. Phytomedicine. 2008; 15(8): 639-52. https://doi.org/10.1016/j.phymed.2008.06.008
- Miladi H, Zmantar T, Chaabouni Y, Fedhila K, Bakhrouf A, Mahdouani K, et al. Antibacterial and efflux pump inhibitors of thymol and carvacrol against food-borne pathogens. Microbial Pathogenesis. 2016; 99: 95-100. Epub 20160809. https://doi.org/10.1016/j.micpath.2016.08.008
- Rosato A, Vitali C, De Laurentis N, Armenise D, Antonietta Milillo M. Antibacterial effect of some essential oils administered alone or in combination with Norfloxacin. Phytomedicine. 2007; 14(11): 727-32. Epub 20070215. https://doi.org/10.1016/j.phymed.2007.01.005
- Mittal RP, Rana A, Jaitak V. Essential oils: An impending substitute of synthetic antimicrobial agents to overcome antimicrobial resistance. Current Drug Targets. 2019; 20(6): 605-24. https://doi.org/10.2174/1389450119666181031122917
- Nourbakhsh F, Lotfalizadeh M, Badpeyma M, Shakeri A, Soheili V. From plants to antimicrobials: Natural products against bacterial membranes. Phytotherapy Research. 2022; 36(1): 33-52. https://doi.org/10.1002/ptr.7275
- Urooj S, Mirani ZA, Pathan FA, Mustafa G, Aziz M, Jabeen B, et al. Silicon nanoparticles: A promising approach for control of Pseudomonas aeruginosa biofilms. Iranian Journal of Basic Medical Sciences. 2023; 26(12): 1475.
- Ovchinnikov E, Silanteva T, Stogov M, Diuriagina O, Godovykh N, Kubrak N. Suppression of Staphylococcus aureus biofilm formation under a short-term impact of low-intensity direct current in vitro and in a rat model of implant-associated osteomyelitis. Iranian Journal of Basic Medical Sciences. 2024; 27(2): 247.
- Nourbakhsh F, Nasrollahzadeh MS, Tajani AS, Soheili V, Hadizadeh F. Bacterial biofilms and their resistance mechanisms: a brief look at treatment with natural agents. Folia Microbiologica. 2022; 67(4): 535-54. https://doi.org/10.1007/s12223-022-00955-8
- Haskins JT. Generalized anxiety disorder. Epidemiology, impact of comorbidity, and natural history. Postgraduate Medical. 1999; 106(6 Suppl): 3-9.
- Altunoz U, Kokurcan A, Kirici S, Bastug G, Ozel-Kizil ET. Clinical characteristics of generalized anxiety disorder: older vs. young adults. Nordic Journal of Psychiatry. 2018; 72(2): 97-102. Epub 20171024. https://doi.org/10.1080/08039488.2017.1390607
- Bandelow B, Michaelis S, Wedekind D. Treatment of anxiety disorders. Dialogues in Clinical Neuroscience. 2017; 19(2): 93-107. https://doi.org/10.31887/DCNS.2017.19.2/bbandelow
- de Sousa DP, de Almeida Soares Hocayen P, Andrade LN, Andreatini R. A systematic review of the anxiolytic-like effects of essential oils in animal Models. Molecules. 2015; 20(10): 18620-60. Epub 20151014. https://doi.org/10.3390/molecules201018620
- Shirzadegan R, Gholami M, Hasanvand S, Birjandi M, Beiranvand A. Effects of Geranium aroma on anxiety among patients with acute myocardial infarction: A triple-blind randomized clinical trial. Complementary Therapies in Clinical Practice. 2017; 29: 201-6. Epub 20171016. https://doi.org/10.1016/j.ctcp.2017.10.005
- Chioca LR, Antunes VD, Ferro MM, Losso EM, Andreatini R. Anosmia does not impair the anxiolytic-like effect of lavender essential oil inhalation in mice. Life Sciences. 2013; 92(20-21): 971-5. Epub 20130406. https://doi.org/10.1016/j.lfs.2013.03.012
- Wang ZJ, Heinbockel T. Essential oils and their constituents targeting the GABAergic System and Sodium channels as treatment of neurological diseases. Molecules. 2018; 23(5). Epub 20180502. https://doi.org/10.3390/molecules23051061
- Watanabe E, Kuchta K, Kimura M, Rauwald HW, Kamei T, Imanishi J. Effects of bergamot ( Citrus bergamia (Risso) Wright & Arn.) essential oil aromatherapy on mood states, parasympathetic nervous system activity, and salivary cortisol levels in 41 healthy females. Forsch Komplementmed. 2015; 22(1): 43-9. Epub 20150219. https://doi.org/10.1159/000380989
- Goepfert M, Liebl P, Herth N, Ciarlo G, Buentzel J, Huebner J. Aroma oil therapy in palliative care: a pilot study with physiological parameters in conscious as well as unconscious patients. Journal of Cancer Research and Clinical Oncology. 2017; 143(10): 2123-9. Epub 20170620. https://doi.org/10.1007/s00432-017-2460-0
- Ceccarelli I, Lariviere WR, Fiorenzani P, Sacerdote P, Aloisi AM. Effects of long-term exposure of lemon essential oil odor on behavioral, hormonal and neuronal parameters in male and female rats. Brain Research. 2004; 1001(1-2): 78-86. https://doi.org/10.1016/j.brainres.2003.10.063
- Kasper S. Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of anxiety disorders and related conditions. Planta Medica. 2010; 76(12): SL_27. https://doi.org/10.1055/s-0030-1264265
- Kasper S, Müller WE, Volz HP, Möller HJ, Koch E, Dienel A. Silexan in anxiety disorders: Clinical data and pharmacological background. The World Journal of Biological Psychiatry. 2018; 19(6): 412-20. Epub 20170619. https://doi.org/10.1080/15622975.2017.1331046
- Singh B, Singh JP, Kaur A, Singh N. Antimicrobial potential of pomegranate peel: a review. International Journal of Food Science & Technology. 2019; 54(4): 959-65. https://doi.org/10.1111/ijfs.13964
- Saleem M, Saeed MT. Potential application of waste fruit peels (orange, yellow lemon and banana) as wide range natural antimicrobial agent. Journal of King Saud University-Science. 2020; 32(1): 805-10. https://doi.org/10.1016/j.jksus.2019.02.013
- Ayala-Zavala JF, Rosas-Domínguez C, Vega-Vega V, González-Aguilar GA. Antioxidant enrichment and antimicrobial protection of fresh-cut fruits using their own byproducts: looking for integral exploitation. Journal of Food Science. 2010; 75(8): R175-81. Epub 20100923. https://doi.org/10.1111/j.1750-3841.2010.01792.x
- Bai MY, Chou TC, Tsai JC, Yu WC. The effect of active ingredient-containing chitosan/polycaprolactone nonwoven mat on wound healing: in vitro and in vivo studies. Journal of Biomedical Materials Research Part A. 2014; 102(7): 2324-33. Epub 20130830. https://doi.org/10.1002/jbm.a.34912
- Ge Y, Ge M. Sustained broad-spectrum antimicrobial and haemostatic chitosan-based film with immerged tea tree oil droplets. Fibers and Polymers. 2015; 16: 308-18. https://doi.org/10.1007/s12221-015-0308-2
- Yurdakök M, Yurdakök K. Topical vegetable oil therapy for premature infants. Journal of Pediatrics. 1997; 130(2): 330-2. https://doi.org/10.1016/S0022-3476(97)70368-8 https://doi.org/10.1016/S0022-3476(97)70367-6
- Nakatsuji T, Kao MC, Fang JY, Zouboulis CC, Zhang L, Gallo RL, et al. Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory Acne vulgaris. Journal of Investigative Dermatology. 2009; 129(10): 2480-8. Epub 20090423. https://doi.org/10.1038/jid.2009.93
- Cádiz-Gurrea ML, Borrás-Linares I, Lozano-Sánchez J, Joven J, Fernández-Arroyo S, Segura-Carretero A. Cocoa and grape seed byproducts as a source of antioxidant and anti-inflammatory proanthocyanidins. International Journal of Molecular Sciences. 2017; 18(2). Epub 20170210. https://doi.org/10.3390/ijms18020376
- Wertz PW. Lipids and barrier function of the skin. Acta dermato-venereologica. Supplementum (Stockh). 2000; 208: 7-11. https://doi.org/10.1080/000155500750042790
- Lawrence BM. A preliminary report on the world production of some selected essential oils and countries. 2009.
- Hardin A, Crandall PG, Stankus T. Essential oils and antioxidants derived from citrus by-products in food protection and medicine: an introduction and review of recent literature. Journal of Agricultural & Food Information. 2010; 11(2): 99-122. https://doi.org/10.1080/10496501003680680
- Brophy JJ, Davies NW, Southwell IA, Stiff IA, Williams LR. Gas chromatographic quality control for oil of Melaleuca terpinen-4-ol type (Australian tea tree). Journal of Agricultural and Food Chemistry. 1989; 37(5): 1330-5. https://doi.org/10.1021/jf00089a027
- Carson CF, Hammer KA, Riley TV. Melaleuca alternifolia (Tea Tree) oil: a review of antimicrobial and other medicinal properties. Clinical Microbiology Reviews. 2006; 19(1): 50-80. https://doi.org/10.1128/CMR.19.1.50-62.2006
- Tisserand R, Young R. Essential oil safety: a guide for health care professionals: Elsevier Health Sciences; 2013. https://doi.org/10.1016/B978-0-443-06241-4.00013-8
- Kelkar VM, Geils BW, Becker DR, Overby ST, Neary DG. How to recover more value from small pine trees: Essential oils and resins. Biomass and Bioenergy. 2006; 30(4): 316-20. https://doi.org/10.1016/j.biombioe.2005.07.009
- McMahon MA, Siliciano JD, Lai J, Liu JO, Stivers JT, Siliciano RF, et al. The antiherpetic drug acyclovir inhibits HIV replication and selects the V75I reverse transcriptase multidrug resistance mutation. Journal of Biological Chemistry. 2008; 283(46): 31289-93. Epub 20080924. https://doi.org/10.1074/jbc.C800188200