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نوع مقاله : مقالات پژوهشی

نویسندگان

1 دانشیار، گروه بهداشت محیط، مرکز تحقیقات عوامل اجتماعی مؤثر بر سلامت، دانشکده بهداشت، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

2 کارشناس ارشد، مهندسی بهداشت محیط، کمیته تحقیقات دانشجویی، دانشکده بهداشت، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

3 دکترای بهداشت محیط، گروه بهداشت محیط، دانشکده بهداشت، دانشگاه علوم پزشکی تهران، تهران، ایران.

چکیده

زمینه و هدف: سیپروفلوکساسین، یکی از مهم‌ترین آنتی‌بیوتیک‌های سنتتیک و از گروه فلوروکوئینولون می‌باشد که کاربرد گسترده‌ای در پزشکی و دامپزشکی دارد. حضور اتم فلوئور در ترکیب آن باعث ایجاد ثبات و پایداری شده است. اخیراً از ازن برای تصفیه فاضلاب، کنترل بو و حذف ترکیبات آلی مقاوم استفاده می­شود. ازن از طریق اکسیداسیون مستقیم و یا مکانیسم واکنش‌های زنجیره‌ای که منجر به تولید رادیکال‌های هیدروکسیل آزاد می‌شود، عمل می­کند. مطالعه حاضر با هدف تعیین کارایی فرآیند ازناسیون در حذف آنتی‌بیوتیک سیپروفلوکساسین از محیط­ های آبی انجام شد.
مواد و روش‌ها:در این مطالعه تجربی ابتدا غلظت ازن تولیدی ژنراتور به روش یدومتریک تعیین گردید. پارامترهای مورد مطالعه در فرآیند شامل: سیپروفلوکساسین با غلظت 50-10 mg/L  تا 50، pH 3 تا 12، مدت زمان واکنش min 60 و میزان ازن برابر 1/4mg/L.min  در راکتور نیمه منقطع انجام شد. غلظت باقی‌مانده سیپروفلوکساسین در نمونه­ ها با استفاده از دستگاه HPLC سنجش شد.
یافته‌ها:در شرایط بهینه شامل pH برابر 12، میزان ازن 1/4mg/L.min  و غلظت اولیه آنتی‌بیوتیک برابر با 10mg/L ، فرآیند ازناسیون قادر بود 94/6 درصد از آنتی‌بیوتیک سیپروفلوکساسین را حذف نماید.
نتیجه‌گیری: ازناسیون می­تواند یک روش مؤثر در حذف آنتی‌بیوتیک سیپروفلوکساسین از محلول­های آبی باشد.

کلیدواژه‌ها

عنوان مقاله [English]

Ciprofloxacin removal by Ozonation from aqueous solutions

نویسندگان [English]

  • Ali Asghar Najafpoor 1
  • omid nemati sani 2
  • hosein alidadi 1
  • aliakbar dehghan 3
  • Saeed Azarmi Moheb Seraj 2

1 Associate Professor, Department of Environmental Health Engineering, Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

2 M.Sc. in Environmental Health Engineering, student research committee, Mashhad University of Medical Sciences, Mashhad, Iran.

3 PhD Student of Environment Health Engineering, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.

چکیده [English]

Introduction: Ciprofloxacin is one of the most important synthetic antibiotics from the fluoroquinolone group and is widely used in medicine and veterinary medicine. The presence of fluorine atom in its composition has made stability and Sustainability. Recently, ozone is used for wastewater treatment, odor control and removal of persistent organic compounds. Ozone acts through direct oxidation or the mechanisms of chain reactions that result in the release of hydroxyl radicals.
Goal: The aim of this study was to determine the efficiency of ciprofloxacin removal by ozonation process from aqueous solutions.
Material and methods: In this study, at first, concentrations of produced ozone of generator were determined by iodometric method. The studied parameters in the process includingciprofloxacin  concentrations of 10-50 mg/L, pH of 3-12, a reaction time of 60 min and an ozone concentration of 1.4 mg/lit.min was investigated in a semiconductor reactor. The remained concentrations of ciprofloxacin in the samples were measured by HPLC.
Results: In the optimal condition, at pH: 12, O3: 1.4 gr/lit.min, and initial antibiotic concentration of 10 mg/L, 94.6% of ciprofloxacin was removed.
Conclusion: The results showed that ozonation can be a suitable method for removal of ciprofloxacin antibiotic from aqueous solutions.

کلیدواژه‌ها [English]

  • " Advanced oxidation "
  • "ciprofloxacin"
  • "HPLC"
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